TCNS: Tributaries of the Central Nervous System
TCNS VIRTUAL August 29, 2020
For the central nervous system (CNS) to function optimally, both the distribution of vital substances to the brain and spinal cord cells and the removal of waste and harmful substances from cells are essential. Fluid flowing throughout the CNS in a regulated and effective way fulfills both delivery and removal requirements.
The focus of this presentation is on CNS fluid production sites, fluid inflow (influx), fluid outflow (efflux), and how disruption of either influx or efflux can lead to CNS disturbance such as neurodegenerative disorders. We will examine the process of cerebrospinal fluid (CSF) production and the glymphatic system — a network of CSF influx and interstitial fluid (ISF) efflux channels. ISF bathes CNS cells. Tad will discuss ISF flow, how this flow differs during the awake and asleep states, and the impact that levels of fluid flow have on CNS cleansing. Also explored is a network of lymphatic vessels embedded within a fascial layer covering the brain and spinal cord. This network of vessels is called the meningeal-lymphatic system. It is within this system that CSF efflux into cervical lymph nodes occurs. Other routes of CSF efflux, such as within the outer layer of blood vessels, are also presented. Additionally, CNS pathology caused by alterations of CNS fluid flow is discussed.
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